(Undergraduate authors underlined)

Z. Tian†, H. Yan†, Y. Zeng*, “Solid-Phase Extraction and Enhanced Amplification-Free Detection of Pathogens Integrated by Dual-Functional CRISPR-Cas12a”, ACS Applied Materials & Interfaces, 2024, Accepted. (Full text)

L. Zheng†, N. Hart†, Y. Zeng*, “Micro-/Nanoscale Robotics for Chemical and Biological Sensing”, Lab on a Chip, 2023, 3741-3767 (Invited Critical Review). (Full text)

• • Featured in the themed collection Lab on a Chip HOT Articles 2023.

H. Yan, S. Han, S. Hughes, Y. Zeng*, “Extraction-Free, One-Pot CRISPR/Cas12a Detection of MicroRNAs Directly from Extracellular Vesicles”, Chemical Communications, 2023, 59, 10165-10168. (Full text)

Z. Tian†, H. Yan†, Y. Zeng*, “Solid-Phase Extraction and Enhanced Amplification-Free Detection of Pathogens Integrated by Dual-Functional CRISPR-Cas12a”, MedRxiv, 2023.04.28.23289279. (Full text)

C. V. Trinidad, H. B. Pathak, S. Cheng, S. Tzeng, R. Madan, M. E. Sardiu, L. E. Bantis, C. Deighan, A. Jewell, Y. Zeng, A. K. Godwin*, “Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer”, Scientific Reports, 2023, 13, 18341. (Full text)

Y. He, Y. Wen, Z. Tian, N. Hart, S. Han, S.J. Hughes, Y. Zeng*, “A One-Pot Isothermal Cas12-based Assay for the Sensitive Detection of MicroRNAs”, Nature Biomedical Engineering, 2023, https://doi.org/10.1038/s41551-023-01033-1. (Full text)

Y. He, Y. Zeng*, “A highly sensitive and robust one-pot assay for the detection of microRNAs”, Nature Biomedical Engineering, 2023, https://doi.org/10.1038/s41551-023-01043-z. (Full text)

N. He, S. Thippabhotla, C. Zhong, Z. Greenberg, L. Xu, Z Pessetto, A. K. Godwin, Y. Zeng, M. He*, “Nano Pom-poms Prepared Exosomes for Highly Specific Cancer Biomarker Detection”, Communications Biology (Nature), 2022, 5, 660. Full text

S. Cheng, Y. Li, H. Yan, Y. Wen, X. Zhou, L. Friedman, Y. Zeng*, “Recent Advances in Microfluidic Extracellular Vesicle Analysis for Cancer Diagnostics”, Lab on a Chip, 2021, 21, 3219-3234 (Invited Critical Review). Full text

• • Selected as part of the themed collection: Lab on a Chip HOT Articles 2021

    

N. He, S. Thippabhotla, C. Zhong, Z. Greenberg, L. Xu, Z Pessetto, A. K. Godwin, Y. Zeng, M. He*, “Nano Pom-poms Prepared Highly Specific Extracellular Vesicles Expand the Detectable Cancer Biomarkers”, bioRxiv, 2021. Full text X. Zhou, H. Cao, Y. Zeng*, “Microfluidic Circulating Reactor System for Sensitive and Automated Duplex-Specific Nuclease-Mediated microRNA Detection”, Talanta, 2021, 232, 122396. Full text

• • • Selected as the cover article

      

H. Yan, Y. Li, S. Cheng, Y. Zeng*, “Advances in Analytical Technologies for Extracellular Vesicles”, Analytical Chemistry, 2021, 93, 11, 4739–4774 (Invited Review). Full text

T.N. Samarasinghe, Y. Zeng, C.K. Johnson*, “Microchip Electrophoresis Assay for Calmodulin Binding Proteins”, Journal of Separation Science, 2021, 44, 895–902. Full text

T.N. Samarasinghe, Y. Zeng, C.K. Johnson*, “Comparison of Separation Modes for Microchip Electrophoresis of Proteins”, Journal of Separation Science, 2021, 44 (3): 744-751. doi: 10.1002/jssc.202000883. Full text

P. Zhang, X. Wu, G. Gardashova, Y. Yang, Y. Zhang, L. Xu*, Y. Zeng*, “Molecular and Functional Extracellular Vesicle Analysis using Nanopatterned Microchips Monitors Tumor Progression and Metastasis”, Science Translational Medicine, 2020, 12, eaaz2878. Full text

• • • Selected as the cover article
    • Featured News: “Liquid Biopsy Method Identifies Cancer Invasiveness and Metastasis”, Cancer Discovery, 2020, June 19

      

B. Chutvirasakul, N. Nuchtavorn, L. Suntornsuk*, Y. Zeng*, “Exosome Aggregation Mediated Stop-Flow Paper-Based Portable Device for Rapid Exosome Quantification”, Electrophoresis, 2020, 41 (5-6), 311-318. Full text

X. Zhou, G.C. Ravichandran, P. Zhang, Y. Zeng*, “A Microfluidic Alternating-Pull-Push Active Digitization Strategy for Reproducible Sample-Loss-Free Digital PCR”, Lab on a Chip, 2019, 19, 4104–4116. Full text

X. Cheng*, Y. Zeng*, “Editorial for the Special Issue on “Micro- and Nanofluidics for Bionanoparticle Analysis”, Micromachines, 2019, 10, 600.

P. Zhang, X. Zhou, Y. Zeng*, “Multiplexed Immunophenotyping of Circulating Exosomes on Nano-engineered ExoProfile Chip towards Early Diagnosis of Cancer”, Chemical Science, 2019, 10, 5495–5504. Full text

P. Zhang, X. Zhou, M. He, Y. Shang, A.L. Tetlow, A.K. Godwin, Y. Zeng*, “Ultrasensitive Detection of Circulating Exosomes with a 3D-Nanopatterned Microfluidic Chip”, Nature Biomedical Engineering, 2019, 3, 438–451. Full text

• • • Featured News on the NIH Director’s Blog: Detecting Cancer with a Herringbone Nanochip
    • Featured News on The Journal of the American Medical Association (JAMA) Network: Biotech Innovations: Novel Nanochip Paves Way for Early Ovarian Cancer Detection
    • Research Highlights on Nature Methods, 16, 286–286: Improved Exosome Detection
    • Editorial: Clever chip designs for diagnostics, Nat. Biomed. Eng., 2019, 3, 417–418.
    • Research News: Enhanced detection of tumour-secreted vesicles, Nat. Biomed. Eng., 2019, 3, 421-422.
    • Featured News on The Pathologist: Game of Exosomes.
    • KU Today News: Breakthrough ‘lab-on-a-chip’ detects cancer faster, cheaper and less invasively.
    • KU Cancer Center News: KU Cancer Center Researchers Develop Novel Lab-on-a-Chip

      

H. Cao, X. Zhou, Y. Zeng*, “Microfluidic Exponential Rolling Circle Amplification for Sensitive microRNA Detection Directly from Biological Samples”, Sensors & Actuators: B. Chemical, 2019, 279, 447-457. Full text

P. Zhang, X. Zhou, Y. Zeng*, “Ultrasensitive analysis of circulating exosomes for liquid biopsy-based cancer diagnosis using 3D nano-engineered microfluidic chips”, Cancer Research, 2019, 79 (13 Supplement), 415.

P. Zhang, J. Crow, D. Lella, X. Zhou, G. Samuel, A.K. Godwin*, Y. Zeng*, “Ultrasensitive Quantification of Tumor mRNAs in Extracellular Vesicles with Integrated Microfluidic Digital Analysis Chip”, Lab on a Chip, 2018, 18, 3790–3801.   Full text

Y. Yang, Y. Zeng*, “Microfluidic Communicating Vessel Chip for Expedited and Automated Immunomagnetic Assays”, Lab on a Chip, 2018, 18, 3830-3839.   Full text

P. Zhang, G. Samuel, J. Crow, A.K. Godwin*, Y. Zeng*, “Molecular Assessment of Circulating Exosomes towards Liquid Biopsy Diagnosis of Ewing Sarcoma Family of Tumors” Translational Research, 2018, S1931-5244(18) 30090-2. (Review).   Full text

K. Li, R. S. Rodosthenous, F. Kashanchi, T. Gingeras, S. J. Gould, L. S. Kuo, P. Kurre, H. Lee, J. N. Leonard, H. Liu, T. B. Lombo, S. Momma, J. P. Nolan, M. J. Ochocinska, D. M. Pegtel, Y. Sadovsky, F. Sánchez-Madrid, K. M. Valdes, K. C. Vickers, A. M. Weaver, K. W. Witwer, Y. Zeng, S. Das, R. L. Raffai, and T. K. Howcroft*, “Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop”, J Clin. Invest. Insight, 2018, 3(7): e98942. (Review).   DOI: 10.1172/jci.insight.98942

M. He, Y. Zeng*, “Microfluidic Exosome Analysis towards Liquid Biopsy for Cancer”, Journal of Laboratory Automation, 2016, 21 (4), 599-608. (invited review)

P. Zhang, M. He, Y. Zeng*, “Ultrasensitive Microfluidic Analysis of Circulating Exosomes Using Nanostructured Graphene Oxide/Polydopamine Coating”, Lab on a Chip, 2016, 16, 3033–3042. (Emerging Investigators Themed Issue).   DOI: 10.1039/C6LC00279J

Y. Wang, K. Southard, Y. Zeng*, “Digital PCR Using Micropatterned Superporous Absorbent Array Chips”, Analyst, 2016, 141, 3821-3831. (invited for the Emerging Investigators themed issue).  DOI: 10.1039/C6AN00164E

Y. Shang, Y. Zeng, Y. Zeng*, “Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling”, Scientific Reports, 2016, 6, 20297.  DOI: 10.1038/srep20297

Z. Zhao, Y. Yang, Y. Zeng*†, M. He*†, “A Microfluidic ExoSearch Device for Multiplexed Exosome Detection Towards Blood-based Ovarian Cancer Diagnosis”, Lab on a Chip, 2016, 16, 489-496  DOI: 10.1039/C5LC01117E

• • • Selected to feature on the inside cover

M. He, A. K. Godwin, Y. Zeng, “Microfluidic Multistage Integration for Analysis of Circulating Exosomes”, in Microfluidic Methods for Molecular Biology, Springer, 2016

M. He, J. Crow, M. Roth, Y. Zeng*, A. K. Godwin*, “Integrated Immunoisolation and Protein Analysis of Circulating Exosomes Using Microfluidic Technology”, Lab on a Chip, 2014, 14, 3773-3780  DOI: 10.1039/C4LC00662C

Y. Zeng, R. A. Mathies, “Droplet-Based Digital Microfluidics for Single-Cell Genetic Analysis”, in Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit, CRC Press-Taylor & Francis Group, 2014

T. Wang, M. Zhang, D. Dreher, Y. Zeng*, “Ultrasensitive Microfluidic Solid-Phase ELISA Using an Actuatable Microwell-Patterned PDMS Chip”, Lab on a Chip, 2013, 13, 4190-4197.  DOI: 10.1039/C3LC50783A

• • • Selected by the Editor as a Lab on a Chip HOT Article (top 10%)

J. Shuga^†, Y. Zeng^†, R. Novak, Q. Lan, X. Tang, N. Rothman, L. Li, A. Hubbard, L. Zhang, R. A. Mathies, M. T. Smith, “Single Molecule Quantitation and Sequencing of Rare Translocations Using Microfluidic Nested Digital PCR”, Nucleic Acids Research, 2013, 41, e159. (^† Equal contribution)   DOI: 10.1039/nar/gkt613

Y. Zeng,* T. Wang, “Quantitative Microfluidic Biomolecular Analysis for Systems Biology and Medicine”, Analytical and Bioanalytical Chemistry, 2013, 405, 5743-5758. (Invited critical review).  DOI: 10.1007/s00216-013-6930-1

Y. Zeng,* M. Shin, T. Wang, “Programmable Active Microfluidic Droplet Generation Enabled by Integrated Pneumatic Micropumps”, Lab on a Chip, 2013, 13, 267-273.  DOI: 10.1039/C4LC00662C

M. He, Y. Zeng, A. B. Jemere, D. J. Harrison, “Tunable thick polymer coatings for on-chip electrophoretic protein and peptide separation”, J. Chromatogr. A, 2012, 1241, 112-116.  DOI: 10.1016/j.chroma.2012.04.009

R. Novak,^† Y. Zeng,^† J. Shuga, G. Venugopalan, D. Fletcher, L. Zhang, M. T. Smith, R. A. Mathies, “Single Cell Multiplex Gene Detection and Sequencing Using Microfluidically-Generated Agarose Emulsions”, Angew. Chem. Int. Ed., 2011, 50, 390-395. (^† Equal contribution)

• • • Selected as a “Hot Paper” by the Editors
    • Highlighted in the frontispiece

      

E. C. Jensen,^† Y. Zeng,^† J. K. Kim, R. A. Mathies, “Microvalve Enabled Digital Microfluidic Systems for High Performance Biochemical and Genetic Analysis”, Journal of Association for Lab Automation, 2010, 15, 455-463. (^† Equal contribution)

J. Shuga, Y. Zeng, R. Novak, R. A. Mathies, P. Hainaut, M. T. Smith, “Selected Technologies for Measuring Acquired Genetic Damage in Humans”, Environmental and Molecular Mutagenesis, 2010, 51, 851-870. (Invited review)

Y. Zeng, R. Novak, J. Shuga, M. T. Smith, R. A. Mathies, “High-Performance Single Cell Genetic Analysis Using Microfluidic Emulsion Generator Arrays”, Anal. Chem., 2010, 82, 3183-3190.

• • • Cover paper;
    • News Focus: “The power of one” Science, 2011, 331, 24-26;
    • Technology Feature: “Clever PCR: more genotyping, smaller volumes” Nature Methods, 2010, 7, 351-355;
    • News: “Detecting extremely rare mutants with single-cell PCR technology” BioTechniques, 2010, April 27

      

M. He, J. Bao, Y. Zeng, D. J. Harrison, “Parameters Governing Flow Properties of Porous Monoliths Photopatterned within Microfluidic Channels”, Electrophoresis, 2010, 31, 2422-2428.

Y. Zeng, M. He, D. J. Harrison, “Microfluidic Self-Patterning of Large-Scale Crystalline Nanoarrays for High-Throughput Continuous DNA Fractionation”, Angew. Chem. Int. Ed.  2008, 47, 6388–6391.

• • • Highlighted in “Another brick in the wall”, www.separationsnow.com, 2010.

M. He, Y. Zeng, X. Sun, D. J. Harrison, “Confinement Effects on the Morphology of Photopatterned Porous Polymer Monoliths for Capillary and Microchip Electrophoresis of Proteins”, Electrophoresis, 2008, 29, 2980-2986.

Y. Zeng, D. J. Harrison, “Self-Assembled Colloidal Arrays as Three-Dimensional Nanofluidic Sieves for Separation of Biomolecules on Microchips”, Anal. Chem., 2007, 79, 2289-2295.

• • • Research Profile: “Nanofluidic sieves ease separation anxiety”, Anal. Chem., 2007, 79, 2611.
    • “Nano-scale ‘sieve’ has really big potential”, Edmonton Journal, 2007.

Y. Zeng, D. J. Harrison, “Confinement Effects on Electromigration of Long DNA Molecules in an Ordered Cavity Array”, Electrophoresis, 2006, 27, 3747-3752.

Y. Zeng, H. Chen, D. W. Pang, Z. L. Wang, J. K. Cheng, “Microchip Capillary Electrophoresis with Electrochemical Detection”, Anal. Chem., 2002, 74, 2441-2445.

H. Chen, Y. Zeng, B. F. Liu, D. W. Pang, J. K. Cheng, “Influence of Soluble Polymer Polyvinylpyrrolidone on Separation of Small Peptides and Amino Acids by Microchip-Based Capillary Electrophoresis”, Anal. Bioanal. Chem., 2002, 373, 314-317.

Y. Zeng, H. Chen, D. W. Pang, Z. L. Wang, J. K. Cheng, “A Novel Microchip-Based Capillary Electrophoresis with Electrochemical Detection and Its Application in Analysis of Neurotransmitters”, Chemical Journal of Chinese Universities, 2002, 23, 567-569.

Y. Zeng, H. Chen, D. W. Pang, Z. L. Wang, J. K. Cheng, “Integrated Microchip-based Capillary Electrophoresis System with Electrochemical Detection”, J. Anal. Sci., 2002, 18, 89-93.

H. Chen, Y. Zeng, B. F. Liu, D. W. Pang, J. K. Cheng, “Microchip-Based Capillary Electrophoresis with LIF-CCD Detection”, J. Anal. Sci., 2001, 17, 93-96.

H. Chen, L. Zhang, B. F. Liu, Y. Zeng, J. K. Cheng, “Improved Resolution in CE Separation of DNA Fragments Using Mixed Polymer Matrix with Hydroxyethylcellose and Polyvinylpyrrolidone”, J. Anal. Sci., 1999, 15, 441-445.